Member Highlight
Q&A with Guangrong Zheng, Ph.D.
Q&A with Guangrong Zheng, Ph.D.
Titles
Associate Professor
Department of Medicinal Chemistry
College of Pharmacy
Research
Dr. Zheng’s lab focuses on the design, synthesis and structure-activity relationship study of both synthetically derived and natural product-based compounds for potential therapeutic uses, or as molecular probes for biochemical/pharmacological research. His research also involves the development of efficient synthetic methodologies and strategies to facilitate the rapid construction of compound libraries.
What are your current research interests and/or what is a project you are currently working on?
My research interests are in the field of drug discovery and development. I am also interested in developing chemical tools to probe biological systems and identify potential drug targets. We are currently working on devising small molecules that can induce targeted protein degradation in cancer cells using a cell’s natural protein degradation machinery. One particular project focuses on developing molecules that can activate programmed cell death in cancer cells through targeted degradation of pro-survival protein Bcl-xL.
What excites you about your work? What is exciting to you about your field right now?
The opportunity to work with many talented people and learn something new every day and the possibility that our discovery may one day change someone’s life. The field is evolving at a rapid pace. Many cool ideas and technologies have emerged in the last several years. I anticipate a number of innovative drugs that are developed by nontraditional approaches will be approved by the FDA in the near future.
What do you want to achieve with your work and/or in your career?
Our team is motivated to make a significant impact on improving cancer therapy. I know that developing a drug is a very big goal and involves thousands of people from many scientific disciplines, but we hope a molecule created in the lab will be effective and safe in treating cancer patients.