Publications
Recent + Selected
Featured Study
Highlights of FOXM1 Research
Relapse is the major cause of death after acute myeloid leukemia (AML) treatment. Leukemia stem cells (LSCs) are a small population of leukemia cells that possess the capacity of enhanced self-renewal and leukemia initiation, and are able to differentiate to bulk leukemia cells. Most LSCs are in a quiescent state, and often evade cytotoxic effects of anticancer drugs, which target rapidly proliferating cells. Therefore, the development of new therapeutic approaches targeting LSCs may be more effective for eradicating leukemia. Our group has identified a vital gene FOXM1 which plays an important function in LSCs —targeting FOXM1 can specifically eliminate LSCs in MLL-rearranged AML. The results are published in the journal Nature Communications recently.
To read more about this study, click here.
Recent Selected Publications
Cancer Population Sciences
Marrero R, Cicali E, Arwood M, Eddy E, DeRemer D, Ramnaraign B, Daily K, Jones D, Cook K, Cavallari L, Weitzel K, Langaee T, Newsom K, Starostik P, Clare-Salzer M, Johnson J, George T, Cooper-DeHoff R. (2020) How to Transition from Single Gene Pharmacogenetic Testing to Preemptive Panel-Based Testing: A Tutorial. Clin. Pharmacol. Ther. ():. PM ID: 32460360
LeLaurin J, Theis R, Thompson L, Tan A, Young-Wolff K, Carter-Harris L, Shenkman E, Salloum R. (2020) Tobacco-Related Counseling and Documentation in Adolescent Primary Care Practice: Challenges and Opportunities. Nicotine Tob. Res. 22(6):1023-1029. PM ID: 31074792
Yadav S, Heller I, Schaefer N, Salloum R, Kittelson S, Wilkie D, Huo J. (2020) The health care cost of palliative care for cancer patients: a systematic review. Support Care Cancer ():. PM ID: 32440909
Salloum R, Lee J, Lee J, Boeckmann M, Xing C, Warren G. (2020) Smoking-Cessation Methods and Outcomes Among Cancer Survivors. Am J Prev Med ():. PM ID: 32446750
Mochona B, Lyon D, Offringa I, Redda K, Reams R, Odedina F, Wilkie D, Stern M, Carpten J. (2020) Developing a Novel Framework for an Undergraduate Cancer Research Education and Engagement Program for Underrepresented Minority Students: the Florida-California CaRE2 Research Education Core (REC) Training Program. J Cancer Educ ():. PM ID: 32430639
Palmier N, Migliorati C, Prado-Ribeiro A, de Oliveira M, Vechiato Filho A, de Goes M, Brandão T, Lopes M, Santos-Silva A. (2020) Radiation-related caries: current diagnostic, prognostic, and management paradigms. Oral Surg Oral Med Oral Pathol Oral Radiol ():. PM ID: 32444333
Im A, Rashidi A, Wang T, Hemmer M, MacMillan M, Pidala J, Jagasia M, Pavletic S, Majhail N, Weisdorf D, Abdel-Azim H, Agrawal V, Al-Homsi A, Aljurf M, Askar M, Auletta J, Bashey A, Beitinjaneh A, Bhatt V, Byrne M, Cahn J, Cairo M, Castillo P, Cerny J, Chhabra S, Choe H, Ciurea S, Daly A, Perez M, Farhadfar N, Gadalla S, Gale R, Ganguly S, Gergis U, Hanna R, Hematti P, Herzig R, Hildebrandt G, Lad D, Lee C, Leslie Lehmann L, Lekakis L, Kamble K, Kharfan-Dabaja M, Khandelwal P, Martino R, Murthy H, Nishihori T, O’Brien T, Olsson R, Patel S, Perales M, Prestidge T, Qayed M, Romee R, Schoemans H, Seo S, Sharma A, Solh M, Strair R, Teshima T, Urbano-Ispizua A, Van der Poel M, Vij R, Wagner J, William B, Wirk B, Yared J, Spellman S, Arora M, Hamilton B. (2020) Risk Factors for Graft-versus-Host Disease in Haploidentical Hematopoietic Cell Transplantation Using Post-Transplant Cyclophosphamide. Biol. Blood Marrow Transplant. ():. PM ID: 32434056
Bates J, Parekh A, Chowdhary M, Amdur R. (2020) Geographic Distribution of Radiation Oncologists in the United States. Pract Radiat Oncol ():. PM ID: 32422395
Bates J, Amdur R, Lee W. (2020) Unfilled Positions in the 2020 Radiation Oncology Residency Match: No Longer an Isolated Event. Pract Radiat Oncol ():. PM ID: 32422396
Kahn J, Brazauskas R, Tecca H, Bo-Subait S, Buchbinder D, Battiwala M, Flowers M, Savani B, Phelan R, Broglie L, Abraham A, Keating A, Daly A, Wirk B, George B, Alter B, Ustun C, Freytes C, Beitinjaneh A, Duncan C, Copelan E, Hildebrandt G, Murthy H, Lazarus H, Auletta J, Myers K, Williams K, Page K, Vrooman L, Norkin M, Byrne M, Diaz M, Kamani N, Bhatt N, Rezvani A, Farhadfar N, Mehta P, Hematti P, Shaw P, Kamble R, Schears R, Olsson R, Hayashi R, Gale R, Mayo S, Chhabra S, Rotz S, Badawy S, Ganguly S, Pavletic S, Nishihori T, Prestidge T, Agrawal V, Hogan W, Inamoto Y, Shaw B, Satwani S. (2020) Subsequent neoplasms and late mortality in children undergoing allogeneic transplantation for nonmalignant diseases. Blood Adv 4(9):2084-2094. PM ID: 32396620 PMC ID: PMC7218429
Uezono H, Indelicato D, Rotondo R, Mailhot Vega R, Bradfield S, Morris C, Bradley J. (2020) Treatment Outcomes Following Proton Therapy for Ewing Sarcoma of the Pelvis. Int. J. Radiat. Oncol. Biol. Phys. ():. PM ID: 32437922
Lyon D. (2020) COVID-19, Cancer, and Financial Toxicity. Oncol Nurs Forum 47(3):253-254. PM ID: 32301928
Zhao Y, Zhang H, Huo J, Guo Y, Wu Y, Prosperi M, Bian J. Mining Twitter to Assess the Determinants of Health Behavior towards Palliative Care in the United States. AMIA Jt Summits Transl Sci Proc. 2020;2020:730-739. Published 2020 May 30.
Zhang H, Gan WT, Hao WG, Wang PF, Li ZY, Chang LJ. Successful Anti-CLL1 CAR T-Cell Therapy in Secondary Acute Myeloid Leukemia. Front Oncol. 2020;10:685. Published 2020 May 27. doi:10.3389/fonc.2020.00685
Kim YY, Wynn TT, Reith JD, Slayton WB, Lagmay J, Fort J, Rajderkar DA. Primary pulmonary artery sarcoma in the pediatric patient: Review of literature and a case report. Radiol Case Rep. 2020;15(7):1110-1114. Published 2020 May 24. doi:10.1016/j.radcr.2020.05.016
Wilkerson JL, Deba F, Crowley ML, Hamouda AK, McMahon LR. Advances in the In vitro and In vivo pharmacology of Alpha4beta2 nicotinic receptor positive allosteric modulators. Neuropharmacology. 2020;168:108008. doi:10.1016/j.neuropharm.2020.108008
Yaghjyan L, Wijayabahu A, Eliassen AH, Colditz G, Rosner B, Tamimi RM. Associations of aspirin and other anti-inflammatory medications with mammographic breast density and breast cancer risk [published online ahead of print, 2020 May 31]. Cancer Causes Control. 2020;10.1007/s10552-020-01321-0. doi:10.1007/s10552-020-01321-0
Kerr AR, Robinson ME, Meyerowitz C, Morse DE, Aguilar ML, Tomar SL, Guerrero L, Caprio D, Kaste LM, Makhija SK, Mungia R, Rasubala L, Psoter WJ. Cues used by dentists in the early detection of oral cancer and oral potentially malignant lesions: findings from the National Dental Practice-Based Research Network [published online ahead of print, 2020 May 23]. Oral Surg Oral Med Oral Pathol Oral Radiol. 2020;S2212-4403(20)31011-7. doi:10.1016/j.oooo.2020.05.007
Cancer Therapeutics & Host Response
Marrero R, Cicali E, Arwood M, Eddy E, DeRemer D, Ramnaraign B, Daily K, Jones D, Cook K, Cavallari L, Weitzel K, Langaee T, Newsom K, Starostik P, Clare-Salzer M, Johnson J, George T, Cooper-DeHoff R. (2020) How to Transition from Single Gene Pharmacogenetic Testing to Preemptive Panel-Based Testing: A Tutorial. Clin. Pharmacol. Ther. ():. PM ID: 32460360
Folch E, Labarca G, Ospina-Delgado D, Kheir F, Majid A, Khandhar S, Mehta H, Jantz M, Fernandez-Bussy S. (2020) Sensitivity and Safety of Electromagnetic Navigation Bronchoscopy for Lung Cancer Diagnosis: Systematic Review and Meta-analysis. Chest ():. PM ID: 32450240
Salloum R, Lee J, Lee J, Boeckmann M, Xing C, Warren G. (2020) Smoking-Cessation Methods and Outcomes Among Cancer Survivors. Am J Prev Med ():. PM ID: 32446750
Lessard C, Rodriguez E, Ladd T, Minter L, Osborne B, Miele L, Golde T, Ran Y. (2020) γ-Secretase modulators exhibit selectivity for modulation of APP cleavage but inverse γ-secretase modulators do not. Alzheimers Res Ther 12(1):61. PM ID: 32430033 PMC ID: PMC7236921
Im A, Rashidi A, Wang T, Hemmer M, MacMillan M, Pidala J, Jagasia M, Pavletic S, Majhail N, Weisdorf D, Abdel-Azim H, Agrawal V, Al-Homsi A, Aljurf M, Askar M, Auletta J, Bashey A, Beitinjaneh A, Bhatt V, Byrne M, Cahn J, Cairo M, Castillo P, Cerny J, Chhabra S, Choe H, Ciurea S, Daly A, Perez M, Farhadfar N, Gadalla S, Gale R, Ganguly S, Gergis U, Hanna R, Hematti P, Herzig R, Hildebrandt G, Lad D, Lee C, Leslie Lehmann L, Lekakis L, Kamble K, Kharfan-Dabaja M, Khandelwal P, Martino R, Murthy H, Nishihori T, O’Brien T, Olsson R, Patel S, Perales M, Prestidge T, Qayed M, Romee R, Schoemans H, Seo S, Sharma A, Solh M, Strair R, Teshima T, Urbano-Ispizua A, Van der Poel M, Vij R, Wagner J, William B, Wirk B, Yared J, Spellman S, Arora M, Hamilton B. (2020) Risk Factors for Graft-versus-Host Disease in Haploidentical Hematopoietic Cell Transplantation Using Post-Transplant Cyclophosphamide. Biol. Blood Marrow Transplant. ():. PM ID: 32434056
Panagiotou O, Högg L, Hricak H, Khleif S, Levy M, Magnus D, Murphy M, Patel B, Winn R, Nass S, Gatsonis C, Cogle C. (2020) Clinical Application of Computational Methods in Precision Oncology: A Review. JAMA Oncol ():. PM ID: 32407443
Kharod S, Nichols R, Henderson R, Morris C, Pham D, Seeram V, Jones L, Antonio-Miranda M, Huh S, Li Z, Hoppe B. (2020) Image-guided hypofractionated double-scattering proton therapy in the management of centrally-located early-stage non-small cell lung cancer. Acta Oncol ():1-7. PM ID: 32394776
Rahman M, Sawyer W, Lindhorst S, Deleyrolle L, Harrison J, Karachi A, Dastmalchi F, Flores-Toro J, Mitchell D, Lim M, Gilbert M, Reardon D. (2020) Adult Immuno-Oncology: Using Past Failures to Inform the Future. Neuro-oncology ():. PM ID: 32391559
Munley J, Chang M, Thomas R. (2020) Intraductal Oncocytic Papillary Neoplasm of the Pancreas. J. Gastrointest. Surg. ():. PM ID: 32394127
Partain B, Unni M, Rinaldi C, Allen K. (2020) The clearance and biodistribution of magnetic composite nanoparticles in healthy and osteoarthritic rat knees. J Control Release 321():259-271. PM ID: 32004585
Shen C, Sheng Y, Zhu A, Robinson S, Jiang X, Dong L, Chen H, Su R, Yin Z, Li W, Deng X, Chen Y, Hu Y, Weng H, Huang H, Prince E, Cogle C, Sun M, Zhang B, Chen C, Marcucci G, He C, Qian Z, Chen J. (2020) RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia. Cell Stem Cell ():. PM ID: 32402250
Drusbosky L, Cogle C. (2020) Identification of Lenalidomide Sensitivity and Resistance Mechanisms in Non-Del(5q) Myelodysplastic Syndromes. Int J Mol Sci 21(9):. PM ID: 32397113
Uezono H, Indelicato D, Rotondo R, Mailhot Vega R, Bradfield S, Morris C, Bradley J. (2020) Treatment Outcomes Following Proton Therapy for Ewing Sarcoma of the Pelvis. Int. J. Radiat. Oncol. Biol. Phys. ():. PM ID: 32437922
Xie H, Kaye F, Isse K, Sun Y, Ramoth J, French D, Flotte T, Luo Y, Saunders L, Mansfield A. (2020) Delta-like Protein 3 Expression and Targeting in Merkel Cell Carcinoma. Oncologist ():. PM ID: 32372416
Zhang X, He Y, Zhang P, Budamagunta V, Lv D, Thummuri D, Yang Y, Pei J, Yuan Y, Zhou D, Zheng G. (2020) Discovery of IAP-recruiting BCL-XL PROTACs as potent degraders across multiple cancer cell lines. Eur J Med Chem 199():112397. PM ID: 32388279
Carbajal-Mamani S, Chheda N, Esnakula A, Cardenas-Goicoechea J. Human papilloma virus-associated metachronous squamous cell carcinoma of the larynx and uterine cervix: Case report and review of the literature. Gynecol Oncol Rep. 2020;32:100568. Published 2020 Apr 7. doi:10.1016/j.gore.2020.100568
Khan S, He Y, Zhang X, Yuan Y, Pu S, Kong Q, Zheng G, Zhou D. PROteolysis TArgeting Chimeras (PROTACs) as emerging anticancer therapeutics [published online ahead of print, 2020 May 31]. Oncogene. 2020;10.1038/s41388-020-1336-y. doi:10.1038/s41388-020-1336-y
Wilkerson JL, Deba F, Crowley ML, Hamouda AK, McMahon LR. Advances in the In vitro and In vivo pharmacology of Alpha4beta2 nicotinic receptor positive allosteric modulators. Neuropharmacology. 2020;168:108008. doi:10.1016/j.neuropharm.2020.108008
Bush R, Johns F, Betty Z, Goldstein S, Horn B, Shoemaker L, Upadhyay K. BK virus encephalitis and end-stage renal disease in a child with hematopoietic stem cell transplantation [published online ahead of print, 2020 May 15]. Pediatr Transplant. 2020;e13739. doi:10.1111/petr.13739
Brumley DA, Gunasekera SP, Chen QY, Paul VJ, Luesch H. Discovery, Total Synthesis, and SAR of Anaenamides A and B: Anticancer Cyanobacterial Depsipeptides with a Chlorinated Pharmacophore. Org Lett. 2020;22(11):4235-4239. doi:10.1021/acs.orglett.0c01281
Lazaryan A, Dolan M, Zhang MJ, Wang HL, Kharfan-Dabaja MA, Marks DI, Bejanyan N, Copelan E, Majhail NS, Waller EK, Chao N, Prestidge T, Nishihori T, Kebriaei P, Inamoto Y, Hamilton B, Hashmi SK, Kamble RT, Bacher U, Hildebrandt GC, Stiff PJ, McGuirk J, Aldoss I, Beitinjaneh AM, Muffly L, Vij R, Olsson RF, Byrne M, Schultz KR, Aljurf M, Seftel M, Savoie ML, Savani BN, Verdonck LF, Cairo MS, Hossain N, Bhatt VR, Frangoul HA, Abdel-Azim H, Malki MA, Munker R, Rizzieri D, Khera N, Nakamura R, Ringdén O, van der Poel M, Murthy HS, Liu H, Mori S, De Oliveira S, Bolaños-Meade J, Elsawy M, Barba P, Nathan S, George B, Pawarode A, Grunwald M, Agrawal V, Wang Y, Assal A, Caro PC, Kuwatsuka Y, Seo S, Ustun C, Politikos I, Lazarus HM, Saber W, Sandmaier BM, De Lima M, Litzow M, Bachanova V, Weisdorf D; Acute Leukemia Committee of the CIBMTR. Impact of cytogenetic abnormalities on outcomes of adult Philadelphia-negative acute lymphoblastic leukemia after allogeneic hematopoietic stem cell transplantation: a study by the Acute Leukemia Working Committee of the Center for International Blood and Marrow Transplant Research. Haematologica. 2020;105(5):1329-1338. doi:10.3324/haematol.2019.220756
Campbell K, Naranjo A, Hibbitts E, et al. Association of heterogeneous MYCN amplification with clinical features, biological characteristics and outcomes in neuroblastoma: A report from the Children’s Oncology Group. Eur J Cancer. 2020;133:112-119. doi:10.1016/j.ejca.2020.04.007
Fullerton A, Mou Y, Silver N, Chheda N, Bolser DC, Wheeler-Hegland K. Impact of Tussigenic Stimuli on Perceived Upper Airway Sensation and Motor Cough Response Following Total Laryngectomy. Front Physiol. 2020;11:477. Published 2020 May 29. doi:10.3389/fphys.2020.00477
Zhang X, Santos R, Debevec G, Li D, Schutte R, Pham K, Liu C, Ostrov DA, Giulianotti M. Identification of small molecules by screening a mixture-based scaffold compound library for treatment of alpha-1 antitrypsin deficiency. Biochem Biophys Res Commun. 2020;527(1):317-323. doi:10.1016/j.bbrc.2020.04.037
Mechanisms of Oncogenesis
Casellas Román H, Venugopal K, Feng Y, Shabashvili D, Posada L, Li J, Guryanova O . (2020) DNMT3A alterations associated with myeloid malignancies dictate differential responses to hypomethylating agents. Leuk. Res. 94():106372. PM ID: 32445940
Shen C, Sheng Y, Zhu A, Robinson S, Jiang X, Dong L, Chen H, Su R, Yin Z, Li W, Deng X, Chen Y, Hu Y, Weng H, Huang H, Prince E, Cogle C, Sun M, Zhang B, Chen C, Marcucci G, He C, Qian Z, Chen J. (2020) RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia. Cell Stem Cell ():. PM ID: 32402250
Xie H, Kaye F, Isse K, Sun Y, Ramoth J, French D, Flotte T, Luo Y, Saunders L, Mansfield A. (2020) Delta-like Protein 3 Expression and Targeting in Merkel Cell Carcinoma. Oncologist ():. PM ID: 32372416
Zhang X, He Y, Zhang P, Budamagunta V, Lv D, Thummuri D, Yang Y, Pei J, Yuan Y, Zhou D, Zheng G. (2020) Discovery of IAP-recruiting BCL-XL PROTACs as potent degraders across multiple cancer cell lines. Eur J Med Chem 199():112397. PM ID: 32388279
Khan S, He Y, Zhang X, Yuan Y, Pu S, Kong Q, Zheng G, Zhou D. PROteolysis TArgeting Chimeras (PROTACs) as emerging anticancer therapeutics [published online ahead of print, 2020 May 31]. Oncogene. 2020;10.1038/s41388-020-1336-y. doi:10.1038/s41388-020-1336-y
Kwon HJ, Qing K, Ponnazhagan S, Wang XS, Markusic DM, Gupte S, Boye SE, Srivastava A. Adeno-Associated Virus D-Sequence-Mediated Suppression of Expression of a Human Major Histocompatibility Class II Gene: Implications in the Development of Adeno-Associated Virus Vectors for Modulating Humoral Immune Response. Hum Gene Ther. 2020;31(9-10):565-574. doi:10.1089/hum.2020.018